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| Titel: |
Evaluation of reproductive toxicity of aqueous extract of the fruits from Caesalpinia ferrea Mart. in rats |
| Auteur: |
José C. T. Carvalho Luciana V. Borges Martha O. Guerra Síntia O. Souza Vera M. Peters |
| Verschenen in: |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Paginering: | Jaargang 7 (2008) nr. 5 pagina's 268-272 |
| Jaar: |
2008 |
| Inhoud: |
Caesalpinia ferrea Mart. (Caesalpinaceae) presents therapeutic potential as antifungal, antiulcer, antiinflammatory, analgesic, and antineoplastic. In the present paper, the toxicity of C. ferrea administered to female rats during the period of blastocyst implantation (5th to 7th day of pregnancy) was evaluated. Thirty inseminated Wistar rats were randomly distributed into Control and Treated groups, which received, by gavage, 0.5 mL of distilled water and 300 mg/kg body weight of C. ferrea, diluted in 0.5 mL of distilled water, respectively. Maternal toxicity was indirectly assessed through: body weight, food and water intake, locomotor activity, piloerection, diarrhea, vaginal bleeding, liver and kidneys weight, and deaths. Rats were killed on the 15th day of pregnancy, when fetuses and placentae were removed and weighed. The number of corpora lutea, implantations, resorptions, and living and dead fetuses were recorded. The index of implantation and the proportion of resorptions were calculated. None of the variables analyzed showed significant differences. In the dose administered in the experimental model used, C. ferrea does not seem to be toxic to the mother nor interfere with blastocyst implantation. |
| Uitgever: |
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 6 gevonden artikelen
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