|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 5 van 7 gevonden artikelen
| Titel: |
On the preclinical anti-trypanosomal, anti-inflammatory and toxicological activities of H. linifolium (L.) G. Don and its diphyllin derivatives |
| Auteur: |
Anibal Zaidenberg Guillermo Schinella José M. Prieto |
| Verschenen in: |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Paginering: | Jaargang 7 (2008) nr. 4 pagina's 225-228 |
| Jaar: |
2008 |
| Inhoud: |
Haplophyllum linifolium (L.) G. Don -synonym H. hispanicum Spach- is an endemic species of the East of Spain, with topical antiinflammatory and antitrypanosome activities. In this work we aim to further gain insight into these activities by A) evaluating the efficacy of the methanolic plant extract in a TPA-induced chronic model of topical inflammation in mouse ear is and B) test the effect of two arylnaphthalene lignans, diphyllin apioside (1) and diphyllin acetylapioside (2) against epimastigotes of T. cruzi in axenic cultures. Our results, show that the diphyllin derivatives (1) and (2) present therein are only endowed with a mild in vitro antitrypanosome activity, with IC50 values of 62.9 and 60.1 µM, respectively, being toxic to normal mammal cells at the same concentration. On the other hand the plant methanolic extract exhibits a potent topical toxicity, causing necrosis of the skin, when applied chronically. The benefits and risks of therapies involving H. linifolium (L.) G. Don extracts or derivate products must be carefully balanced and always done under tight medical control. |
| Uitgever: |
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 7 gevonden artikelen
| << vorige | volgende >> |
Toegankelijkheidsverklaring