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| Titel: |
An ethanolic extract of Uncaria tomentosa reduces inflammation and B16- BL6 melanoma growth in C57BL/6 mice |
| Auteur: |
Ana Laura Fazio Diana Ballén Italo M. Cesari María Jesús Abad Miriam Arsenak Peter Taylor |
| Verschenen in: |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Paginering: | Jaargang 7 (2008) nr. 4 pagina's 217-224 |
| Jaar: |
2008 |
| Inhoud: |
Extracts of the bark of Uncaria tomentosa (Cat is Claw ¿ Uña de Gato) have been used traditionally for their anti-inflammatory and anticancer properties. We investigated the effect of a hydroethanolic extract (UT) of U. tomentosa on a) the viability of primary and tumor cells, b) the inflammatory response (tumor necrosis factor alpha [TNF-α], interleukin-6 [IL-6] and nitric oxide [NO]) both in vitro and in vivo, c) B16/BL6 melanoma cell growth and metastasis in the C57BL/6 mouse, and d) nuclear factor κB (NF-κB) activity in LPS-stimulated HeLa cells. UT did not show an important cytotoxic effect in vitro at the doses up to 300 μg/ml, but did inhibit tumor growth and metastasis in vivo. UT inhibited TNF-α, IL-6 and NO production in vitro. NF-κB activity was also inhibited. Our studies show that UT merits further study for its effects on processes common to inflammation and cancer. |
| Uitgever: |
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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