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Details van artikel 5 van 9 gevonden artikelen
| Titel: |
In vitro and in vivo activity of berberine on the blood trypomastigote from Trypanosoma cruzi |
| Auteur: |
Anibal Zaidenberg Guillermo Schinella Horacio Tournier |
| Verschenen in: |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Paginering: | Jaargang 6 (2007) nr. 3 pagina's -81---85 |
| Jaar: |
2007 |
| Inhoud: |
Blood transfusion has been found to be an important mechanism in the transmission of the Chagas disease and there is a need for new agents able to inhibit the infectiveness of Trypanosoma cruzi in stored blood. The methanolic extract of the root of Coptis chinensis and the alkaloid berberine has been previously identified as effective trypanicidal agents both in vitro and in vivo and could be promising prophylactic drugs to address this issue. The extract of C. chinensis and its main bioactive, berberine, resulted more active against Bra C15C2 clone epimastigotes in axenic cultures than allopurinol, the antitrypanosomal drug of reference, with IC50 values of 1.7 µ/ml and 0.3 µg/ml (0.81 µM), respectively. The in vitro anti-trypanosomal activities of the methanolic extract of roots of C. chinensis and its main bioactive, berberine, were tested using epimastigotes of the clon Bra C15C2. Berberine (250 µg/ml) and crystal violet were equally effective in preventing transfusion-mediated infection of CF1 mice with the clon H510C8C3. However berberine (30 mg/kg/day, p.o.) for 30 days was unable to enhance the survival of already infected animals. The mechanism of protection may encompass both diminished parasitaemia in stored blood as well as inactivation of the infectiveness of the parasites, opening a new perspective in the fight against Trypanosomiasis. |
| Uitgever: |
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 9 gevonden artikelen
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