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| Titel: |
Effect of Ethanolic Extract of pluchea ovalis root in Asthma model of Wistar Rat |
| Auteur: |
José María Prieto |
| Verschenen in: |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Paginering: | Jaargang 4 (2005) nr. 3 pagina's -52-59 |
| Jaar: |
2005 |
| Inhoud: |
The extract of Pluchea ovalis root is orally used in the treatment of asthma, which is a chronic inflammatory disease characterized by bronchoconstriction, inflammatory cell infiltration, and plasma extravasation into the airway. The purpose of this study was to investigate the effect of the ethanolic extract on some asthma parameters. Using sensitized rats treated with the extract, we determined the effect of histamine on the trachea in vivo, the leukocyte number and Evans blue dye in the bronchoalveolar fluid. We have also examined the effect of the extract on rat isolated trachea in the presence of histamine in three different conditions of incubation: (1) indomethacin, (2) indomethacin + propranolol and (3) indomethacin + propranolol + atropine. Our results show that P. ovalis extract significantly reduced the increase of pulmonary inflation pressure induced by histamine in vivo, the leukocyte infiltration and, partially, the plasma extravasation into the airway. The extract inhibited the trachea contraction in all three conditions. We conclude that the ethanolic extract of P. ovalis root significantly reduces asthmatic symptoms in asthma model in Wistar rats |
| Uitgever: |
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 9 gevonden artikelen
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