Diuretic activity of hot flower infusion of nyctanthes arbo-tristis in rats
Titel:
Diuretic activity of hot flower infusion of nyctanthes arbo-tristis in rats
Auteur:
J. R. A. C. Jayakody W.D. Ratnasooriya
Verschenen in:
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas
Paginering:
Jaargang 3 (2004) nr. 5 pagina's -84--87
Jaar:
2004
Inhoud:
The objective of this study was to evaluate the diuretic potential of Nyctanthus arbotristis Linn. (Oleaceae) flowers using a hot water infusion in rats. Different concentrations of the infusion (3.7, 7.5, 12.5, or 18.7 mg/ kg ), or vehicle, or furosemide (the reference drug at 13 mg/kg), was orally administered to hydrated rats. Their cumulative urine output was monitored at hourly intervals for 6 hours. The flower infusion induced a significant (P<0.05) diuresis in a dose-related manner. The onset of this diuretic action was extremely rapid (within 1 hr) and lasted throughout the study period. Further, the flower infusion caused a significant impairment (P<0.05) of the urinary Na+ and K+ levels and caused slight but significant (P<0.05) alkalisation. However, it had no significant (P>0.05) effect on urine specific gravity or Na+/K+ ratio of urine. Collectively, these data suggest that the infusion induces diuresis by basically acting as a potassium sparing diuretic. It is concluded that these flowers have a promising potential as a safe, effective and cheap diuretic
Uitgever:
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ)
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