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| Titel: |
Sub-acute Toxicity Study of 3,6-Dimethyl-4-Ethyl-O-Acetyl Benzene Isolated from Soil Streptomyces Species |
| Auteur: |
Bytul M. Rahman M.S.A. Bhuiyan M. Golam Sadik A.S.M. Anisuzzman |
| Verschenen in: |
Biotechnology |
| Paginering: | Jaargang 1 (2002) nr. 2 pagina's 116-120 |
| Jaar: |
2002 |
| Inhoud: |
The sub-acute toxicity study of 3,6-dimethyl-4-ethyl-0-acetyl benzene (BM-5), was carried out on Long Evan`s rats using daily administration (300 �g/rat/day) of compound for 14 consecutive days. Non-significant differences between weight of compound receiving rats and control rats (48�0.816 vs 46�0.816) were found. The change in hematological parameters was found to be nonsignificant (total count of RBC, 5.1�0.081 vs 4.63�0.094; white blood cell, 7.33�0.124 vs 5.73�0.124; platelets, 361666�10274 vs 261666�8498, (cell/ml) �106; percentage of hemoglobin 65.67�1.60 vs 56�0.816; ESR, 25�0.816 vs 19.67�0.471 for experimental and control rats, respectively) and biochemical parameters (serum glutamate pyruvate transaminase, 8.5�0.408 vs 8.33 �0.471 IU L-1; serum glutamate oxaloacetate transaminase, 9.83�0.235 vs 9.33�0.234 IU L-1; bilirubin, 0.36�0.104 vs 0.34�0.016 �g dL-1; creatinine, 0.67 �0.089 vs 0.61�0.009 mg dL-1; urea, 18.83�0.235 vs 18.5�0.408 mg dL-1; for experimental and control rats). Therefore, the changes in body weight, hematological and biochemical parameters were statistically non-significant. No detectable abnormalities were found in histopathology of heart, kidney, liver and lung in experimental group of rats as compared with that of the control group of rats. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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