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| Titel: |
Protein kinase ASK1 as potential therapeutic target |
| Auteur: |
VOLYNETS G. P. Bdzhola V. G. Kukharenko O. P. Sovetova O. V. Yarmoluk S. M. |
| Verschenen in: |
Biopolymers and cell |
| Paginering: | Jaargang 25 (2009) nr. 3 pagina's 169-180 |
| Jaar: |
2009 |
| Inhoud: |
Apoptosis signal-regulating kinase 1 (ASK1) is serine/threonine kinase of kinase 5 that activates MAP-kinase (MAPKKK5). ASK1 induces apoptosis via the JNK and p38 signaling pathways. This review is focused on three main characteristics of ASK1: the structure , the regulatory mechanisms of kinase activity and the physiological role. ASK1 is required for apoptosis induced by oxidative stress, TNF-a, Fas and endoplasmic reticulum. It also regulates differentiation and death of neurons. ASK1 has been shown to be required for the innate immune response. This kinase is a critical signaling molecule for cardiac hypertrophy and remodeling. ASK1 also accelerates endothelial cell senescence in diabetic patients. Inhibition of the ASK1-p38 pathway could be useful for preventing vascular ageing and treatment of neurodegenerative and cardiac diseases. |
| Uitgever: |
Institute of molecular biology and genetics, National Academy of Sciences of Ukraine (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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