Screening of selected medicinal plants for urease inhibitory activity
Titel:
Screening of selected medicinal plants for urease inhibitory activity
Auteur:
Tahseen Ghous
Verschenen in:
Biology and medicine
Paginering:
Jaargang 2 (2010) nr. 4 pagina's 64-69
Jaar:
2010
Inhoud:
In this study, we have investigated antiurease activity of eleven Et-OH and five Me-OH extracts of medicinal plantscollected from the State of Kashmir. Selection of the plants was made on the basis of their uses by local people andherbalists for the treatment of different ailments including stomach problems. In the study Et-OH extracts of Sussurialappa, Malva parviflora, Solanum nigrum, and Melia azadirachta were found inactive or showed low activity at final ofconcentration 200μg/ 5ml. While Et-OH extracts of Taraxacum officinale, Achillea millefolium, Aristolachia bracteata,Eucalyptus globules, Adhatoda zeylanica, Cuscuta reflexa and Mentha longifolia showed stronger action againsturease activity. The IC50 values for these extracts were 33.33*, 94.24, 68.62, 66.91, 83.33, 89.19 and 57.47*μg/ 5ml.Among Me-OH extracts, Achillea millefolium and Aristolachia bracteata demonstrated stronger antiurease activityIC50=60.29* and 58.73*μg/5ml. Mentha longifolia, Solanum nigrum and Melia azadirachta showed no action againsturease activity at 200μg/ 5ml. Results of this study illustrate that most of the studied extracts exhibited reasonableantiurease activity, however, ethanolic extracts of Taraxacum officinale, Mentha longifolia and methanolic extracts ofAchillea millefolium and Aristolachia bracteata showed significant inhibition potential. Our findings may help to explainthe beneficial effects of these plant extracts against stomach infection associated with pathogenic strains of H. pylori.The crude extracts may be purified for the isolation of compounds with antiurease activity. These results also validatethe traditional use of these herbs for the treatment of stomach infection.
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