Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphylla stem extract in streptozotocin induced diabetic rats
Titel:
Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphylla stem extract in streptozotocin induced diabetic rats
Auteur:
KS Dangi
Verschenen in:
Biology and medicine
Paginering:
Jaargang 2 (2010) nr. 4 pagina's 35-44
Jaar:
2010
Inhoud:
Capparis aphylla, a xerophytic plant, has been used in traditional Indian medicine for treating diabetes andcardiovascular disease. The methanol extracts and active fraction from stem of C. aphylla administered todiabetic rats and blood glucose, antioxidant level, lipid, urea and creatinine level were assayed. The single oraldosing(300mg/kg b.wt) of methanol extract and active fraction(30mg/kg b.wt) from stem part of C. aphyllasignificantly reduced blood glucose levels in normal and diabetic rats (p<0.01) during oral glucose tolerance test.While total plasma cholesterol, triglycerides, VLDL and LDL levels were significantly (p<0.01) reduced, serumHDL was elevated by 116% after 7 days of active fraction oral administration in diabetic rats. Active fractiontreatment lead to significant (p<0.01) increase in GSH and decreased MDA level in liver, heart and kidney ofdiabetic rat. Finding supported the traditional use of C. aphylla in the treatment of diabetes and cardiovasculardisease.
Tijdschrift beschrijving