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| Titel: |
Indispensable chemical genomic approaches in novel systemic targeted drug discovery |
| Auteur: |
A Kanikkai Raja |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 2 (2010) nr. 3 pagina's 26-37 |
| Jaar: |
2010 |
| Inhoud: |
Chemogenomics is a new emerging area in the field of drug discovery and development. It describes thedevelopment of target specific chemical ligands and the use of such specific chemical ligands to globally study thegene level and protein level functions. The human genome contains around 100,000 genes and 30,000 proteinswhich are encoded by it. Primarily the novel, systemic, very small molecular sized, cell permeable and target specificchemical ligands are particularly useful in systematic genomic approaches to study the normal and abnormalbiological functions. The complete genomic sequence information with structural and comparative genomics whencombined with all the features in synthetic chemistry, ligand screening and identification provides target or functionsspecific chemical ligands and drugs. Currently, the in-silico approaches are in vogue in novel target prediction andsystemic drug discovery. It is prediction of biological targets of small molecules via data mining in target annotatedchemical databases. This review will focus on the chemogenomics, its approaches for rational drug design and therecent in-silico approaches in novel target prediction. |
| Uitgever: |
E Business Navigators (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 7 van 7 gevonden artikelen
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