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| Titel: |
Levels of plasma testosterone, antioxidants and oxidative stress in alcoholic patients attending de-addiction centre |
| Auteur: |
Sameer R Kulkarni K Pratibha Ravindra CY Dhume P Rataboli Edmond Rodrigues |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 1 (2009) nr. 4 pagina's 11-20 |
| Jaar: |
2009 |
| Inhoud: |
In men chronic heavy drinking interferes with reproductive hormones which are responsible for sexual maturation,sperm development and fertility. Alcohol is directly toxic to the testes; causing reduced testosterone levels.Thepresent study was designed with an aim to elucidate the effect of oxidative stress on plasma testosterone level andhypothalamic pituitary gonadal (HPG) axis function in alcoholics. The plasma testosterone, luteinizing hormone andfollicle stimulating hormone were investigated in alcohols (n=200) (25–45 years) and were compared with normal nonalcoholic controls (n=160). Alcohol abusers displayed significantly lower levels of plasma testosterone, luteinizinghormone, follicle stimulating hormone, Vitamin C, Vitamin E, ß- Carotene, Glutathione and Superoxide Dismutase,Glutathione Reductase activities accompanied with significantly higher levels of Protein carbonyl content andMalondialdehyde levels than controls (P<0.001).Decreased serum testosterone level in alcoholics might be due toincreased oxidative stress and decrease in antioxidant levels. |
| Uitgever: |
E Business Navigators (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 12 gevonden artikelen
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