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| Titel: |
Cardiac responsiveness to beta-adrenergics in rats with lead induced hypertension |
| Auteur: |
Badalzadeh Reza |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 1 (2009) nr. 4 pagina's 75-81 |
| Jaar: |
2009 |
| Inhoud: |
There are controversial reports about the exact mechanisms of lead-induced hypertension, but alteration in theresponsiveness of cardiovascular system to catecholamines may be involved. In the present study, the effect ofexposure to low level of lead acetate on responsiveness of isolated beating heart to β-adrenergics in male ratswas investigated, using Langendorff isolated heart. Animals were randomly divided into 4 groups: control and 4, 8and 12-week lead-treated groups. Lead-treated groups received 100ppm lead acetate in drinking water. Theisolated hearts were perfused with Krebs-Henseleit solution at 37˚C and pH=7.4 under constant pressure andgassed with 95%O2+5%CO2. The blood pressure of anesthetized animals and chronotropic and inotropicresponses of the isolated hearts to β-adrenergics (isoproterenol and dobutamine) were recorded separately andcorresponding dose-response curves were obtained. The blood pressure in 8-and 12-week lead-treated groupswas significantly increased compared with those of the control group (P<0.01). The chronotropic response toisoproterenol in only 12-week lead-treated group was significantly increased. The inotropic response to this drugwas also significantly increased in both 8-and 12-week lead-treated rats (P<0.05). Similar findings were observedwith dobutamine, but the contractile response of the latter agent was greater than the isoproterenol. Our resultsindicate that low-level of lead increases blood pressure and both chronotropic and inotropic effects of β-adrenergics. These effects could imply an important role in the pathogenesis of lead-induced hypertension. |
| Uitgever: |
E Business Navigators (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 12 gevonden artikelen
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