Lipid peroxidation, glutathione, ascorbic acid, vitamin E, antioxidant enzyme and serum homocysteine status in patients with polycystic ovary syndrome
Titel:
Lipid peroxidation, glutathione, ascorbic acid, vitamin E, antioxidant enzyme and serum homocysteine status in patients with polycystic ovary syndrome
Auteur:
Surapaneni Krishna Mohan Vishnu Priya V
Verschenen in:
Biology and medicine
Paginering:
Jaargang 1 (2009) nr. 3 pagina's 44-49
Jaar:
2009
Inhoud:
The exact pro-oxidant and antioxidant status in patients with polycystic ovary syndrome is still not clear. Manystudies suggest that polycystic ovary syndrome may increase risk for several conditions like type 2 diabetes,dyslipidemia, endometrial cancer and hypertension. To add a new insight to the question, changes in theerythrocyte lipid peroxidation products (MDA), glutathione (GSH), ascorbic acid, plasma vitamin E and activitiesof antioxidant enzymes super oxide dismutase (SOD), glutathione peroxidase (GPX), catalase in erythrocyte,plasma glutathione – S – transferase (GST) and serum homocysteine levels were measured in patients withPolycystic Ovary Syndrome. This work was undertaken to assess oxidative stress and antioxidant status inpatients with Polycystic Ovary Syndrome and its contribution to the risk of cardiovascular disease. The study wasconducted in fifty-six patients & compared to controls. Erythrocyte MDA, GSH, ascorbic acid, plasma vitamin Eand activities of antioxidant enzymes SOD, GPX, catalase in erythrocytes, plasma GST and serum homocysteinewere estimated in Polycystic Ovary Syndrome patients. These parameters were measured in fifty-six patients andcompared to controls. It was observed that there was a significant increase in erythrocyte MDA levels, SOD, GPXand plasma GST activities and a significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin E levelsand catalase activity in patients with polycystic ovary syndrome when compared to controls. Serum homocysteinelevels were significantly higher in polycystic ovary syndrome patients than in the controls. The results of our studysuggests higher oxygen free radical production, evidenced by increased MDA and decreased GSH, ascorbicacid, vitamin E and Catalase activity, support to the oxidative stress in polycystic ovary syndrome. The increasedactivities of antioxidant enzymes may be a compensatory regulation in response to increased oxidative stress.Increased homocysteine levels and decreased antioxidant capacity may contribute to the increased risk ofcardiovascular disease in women with PCOS, in addition to known risk factors such as insulin resistance,hypertension, central obesity, and dyslipidemia.
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