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| Titel: |
The influence of chloroquine administration on antioxidant levels, oxidant marker and total cholesterol in Wistar rats |
| Auteur: |
AC Achudume |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 1 (2009) nr. 3 pagina's 39-43 |
| Jaar: |
2009 |
| Inhoud: |
This study was undertaken to determine some biochemical changes of importance associated with chloroquine (CQ)treatment, using rat model of Plasmodium beighei berghei parasites. Chloroquine phosphate (5mg/kg body wt,dissolved in distilled water) was administered 3days per week for 8 weeks after infection by Plasmodium beigheibeighei. The chloroquine did not potentiate any adverse effect on the formation of ascorbic acid-linked lipidperoxidation. The drug increased glutathione contents, but decreased protein and cholesterol levels. Chloroquinealone had no significant effect on malondialdehyde and alanine/aspartate transaminases, but decreased proteinsynthesis and cholesterol level. The characteristic biologic effects of CQ including the decrease in total cholesterol,protein synthesis, and stabilizer of lipid peroxidation as measured by malondialdehyde and the increased level ofglutathione, may enhance the environmental measures of public health in cholesterol compromised individuals. |
| Uitgever: |
E Business Navigators (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 10 gevonden artikelen
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