Chalcones: Differential effects on glycogen contents of liver, brain and spinal cord in rats
Titel:
Chalcones: Differential effects on glycogen contents of liver, brain and spinal cord in rats
Auteur:
H Jamal
Verschenen in:
Biology and medicine
Paginering:
Jaargang 1 (2009) nr. 2 pagina's 107-115
Jaar:
2009
Inhoud:
Chalcones are precursor compounds for flavonoids biosynthesis in plants, and they can also be synthesized inlaboratory. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial,anthelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic andimmunosuppressive. Aldose reductase (AR) enzyme inhibitors have been proposed to prevent or ameliorate longterm diabetic complications. Chalcones showed good level of inhibitory activity towards bovine lens aldose reductase(AR) and have been shown the promising compound for the prevention or treatment of diabetic complications.Although a broad range of biological activities of chalcones have been reported, the mode of action of chalcones onglycogen is not yet elucidated. Chalcones were injected intraperitoneally at the dose of 25mg/kg for seven days. Onthe seventh day, one hour after the last dose rats were killed by cervical decapitation and their liver, brain and spinalcords were dissected out. Our results showed that out the eight tested chalcones, four chalcones significantlyinhibited (P>0.001) the liver glycogen. There are no significant effects of chalcones on brain and spinal cord glycogencontents. In conclusion, chalcones exert their antidiabetic effect by decreasing only the liver glycogen content. Bycomparing the glycogen inhibitory activity structural elements of chalcones responsible for glycogen inhibition couldbe identified.
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