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| Titel: |
Protective role of green tea extract against genotoxic damage induced by anabolic steroids in cultured human lymphocytes |
| Auteur: |
Jyoti Gupta Yasir Hasan Siddique Tanveer Beg Gulshan Ara Mohammad Afzal |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 1 (2009) nr. 2 pagina's 87-99 |
| Jaar: |
2009 |
| Inhoud: |
Tea (Camellia sinensis) is one of the most popular beverages consumed worldwide as an infusion of leaves and isvalued for its medicinal properties. Tea is a rich source of polyphenols called flavonoids, effective antioxidants foundthroughout the plant kingdom. The slight astringent, bitter taste of green tea is attributed to polyphenols. A group offlavonoids in green tea are known as catechins, which are quickly absorbed into the body and are thought tocontribute to some of the potential health benefits of tea. The fresh tea leaves contain four major catechins ascolourless water soluble compounds. epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC) andepigallocatechin gallate (EGCG). Epidemiologic observations and laboratory studies have indicated that teapolyphenols act as antioxidants in vitro by scavenging reactive oxygen and nitrogen species and chelating redoxactivetransition metal ions and hence tea may reduce the risk of a variety of illnesses, including cancer and coronaryheart disease. In this study we seen the antigenotoxic effect of green tea extract against genotoxic damage inducedby two anabolic steroids Trenbolone and Methyltestosterone in cultured human lymphocytes, both in absence andpresence of metabolic activation. The results prove the antigenotoxic potential of green tea extract. Because theepidemiologic studies and research findings in laboratory animals have shown the antigenotoxic potential of teapolyphenols, the usefulness of tea polyphenols for various human diseases like cancer and coronary heart diseaseetc should be evaluated in clinical trials. |
| Uitgever: |
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| Bronbestand: |
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