Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark
Titel:
Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark
Auteur:
Ezekiel O. Iwalewa1, Nusrat O. Omisore1, Oluwatoyin M. Daniyan, Clement O. Adewunmi, Bamigboye J. Taiwo, Oluwatobi A. Fatokun and Isaac O. Oluborode
Verschenen in:
Bangladesh journal of pharmacology
Paginering:
Jaargang 4 (2009) nr. 2 pagina's 115-121
Jaar:
2009
Inhoud:
The concentrations of 15 elements and heavy metals in the stem bark of Harungana madagascariensis were determined using an energy-dispersive X-ray fluorescence (EDXRF) spectrometer. The anti-anemic activity was done using the changes in hematological parameters (PCV, RBC and Hb) influenced by phenylhydrazine HCL (80 mg/kg) and malaria parasites-induced anemia. Results show Cd, Ni, Mo, Cr and Br were in the range of 0.021–0.94 mg/g, while Pb, Zn, Fe, Cu and Hg were in the range of 1.50–7.24 mg/g. The elements with very high concentration were Ca, K, Sr, Mn and Cl and were in the range of 10.5–774.3 mg/g. Remarkable anti-anemic activity was obtained with PCV of 40–48%, RBC count of 81-155 x104 and Hb value of 57-66 g/dL after treatment; compared with 30% PCV, 67 x104 RBC count and 36.5 g/dL Hb value obtained for the untreated control animals. Our results suggest that H. madagascariensis stem bark extract constituents exhibit anti-anemic activity.
Uitgever:
Bangladesh Pharmacological Society (provided by DOAJ)
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