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Details van artikel 5 van 14 gevonden artikelen
| Titel: |
Increased DNA damage in blood cells of rat treated with lead as assessed by comet assay |
| Auteur: |
Mohammad Arif Yearul Kabir Faizule Hassan T.M. Zaved Waise Md. Ehsanul Hoque Mazumder Shafiqur Rahman |
| Verschenen in: |
Bangladesh journal of pharmacology |
| Paginering: | Jaargang 3 (2008) nr. 2 pagina's 97-101 |
| Jaar: |
2008 |
| Inhoud: |
A growing body of evidence suggests that oxidative stress is the key player in the pathogenesis of lead-induced toxicity. The present study investigated lead-induced oxidative DNA damage, if any in rat blood cells by alkaline comet assay. Lead was administered intraperitoneally to rats at doses of 25, 50 and 100 mg/kg body weight for 5 days consecutively. Blood collected on day six from sacrificed lead-treated rats was used to assess the extent of DNA damage by comet assay which entailed measurement of comet length, olive tail moment, tail DNA (%) and tail length. The results showed that treatment with lead significantly increased DNA damage in a dose-dependent manner. Therefore, our data suggests that lead treatment is associated with oxidative stress-induced DNA damage in rat blood cells which could be used as an early bio-marker of lead-toxicity. |
| Uitgever: |
Bangladesh Pharmacological Society (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 14 gevonden artikelen
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