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| Titel: |
Synthesis and preliminary evaluation of brominated 5-methyl-2,4-dihydropyrazol-3-one and its derivatives as cytotoxic agents |
| Auteur: |
Rahat Khan Md. Imam Uddin Md. Sultan Alam Mohammad Mamun Hossain Md. Rabiul Islam |
| Verschenen in: |
Bangladesh journal of pharmacology |
| Paginering: | Jaargang 3 (2008) nr. 1 pagina's 27-35 |
| Jaar: |
2008 |
| Inhoud: |
Derivatives of 5-methyl-2,4-dihydro-pyrazol-3-one (1a), 5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one (1b) and 2-(2,4-dinitro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one (1c) have been brominated in various ways. The compounds (1a, 1b, 1c) were synthesized by condensation reaction between the ethylacetoacetate and hydrazine derivatives. All the products have been characterized by extensive use of IR, 1H-NMR, 13C-NMR and Mass spectral analysis. Investigation of the cytotoxicity of these compounds was carried out against brine shrimp by lethality bioassay. The cytotoxicity studies of the synthesized compounds revealed that compound 4,4-dibromo-2-(2,4-dinitro-phenyl) -5-methyl -2,4-dihydro-pyrazol-3-one (2c) had shown tremendous bioactivity against brine shrimp. However, the compounds 4,4-dibromo-5-methyl-2,4-dihydro-pyrazol-3-one (2a), 4,4-dibromo-2-(2,4-dibromo-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one (2b) and 4,4-dibromo-2-(dinitro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one (2c) showed higher activity leaving the other compounds almost inactive. |
| Uitgever: |
Bangladesh Pharmacological Society (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 7 van 7 gevonden artikelen
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