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  In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered
 
 
Titel: In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered
Auteur: Md. Ashraful Alam, Md. Abdul Awal, Mahbub Mostofa, Md. Kamrul Islam and Nusrat Subhan
Verschenen in: Bangladesh journal of pharmacology
Paginering: Jaargang 2 (2007) nr. 1 pagina's 20-26
Jaar: 2007
Inhoud: The binding of atenolol (selective β1-blocker) and amlodipine (calcium channel blocker) to bovine serum albumin (BSA) was studied by equilibrium dialysis method in order to have an insight into the binding chemistry of these two to BSA. Free atenolol concentration was increased due to addition of amlodipine which reduced the binding of the compounds to BSA. However, the free fraction was increased to a level as it was expected from direct competitive displacement while the free atenolol concentration was increased according to increasing the amlodipine concentration when only the BSA was present. The result obtained when the binding site was blocked by sufficient amount of amlodipine was that the increment of free concentration of atenolol was prominent. When no amlodipine was added the free concentration of atenolol was only 28% whereas this release was 93 % to 98.01% when amlodipine was added with increasing concentration.
Uitgever: Bangladesh Pharmacological Society (provided by DOAJ)
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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