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Details for article 4 of 10 found articles
| Title: |
Desarrollo y validación de un método espectrofluorométrico para la determinación de furosemida en formas farmacéuticas sólidas |
| Author: |
Alexis Buitrago Laura Calderón Andrés León Rosario Brunetto Máximo Gallignani |
| Appeared in: |
Avances en Química |
| Paging: | Volume 5 (2010) nr. 1 pages 15-25 |
| Year: |
2010 |
| Contents: |
The aims of this work is to develop and validate an alternative analytic method by spectrofluorometry for the quality control of Furosemide in solid pharmaceutical forms based on the native fluorescence of the molecule in acidic medium (λExc.= 280nm and λEmi.= 410nm). This method allows to determine Furosemide in a buffer solution of potassium chloride-hydrochloric acid 50 mM (pH 2.0) in a range of 1.45x10-7 to 1.51x10-5 mol L-1 (4.5 to 5000 ng mL-1), with an estimated detection limit of 4.84x10-8 -mol L-1 (1.5 ng mL-1). The proposed method offers, as competitive advantages comparing to the official method reported in the United States Pharmacopeia (USP 29), its simplicity, low cost and frequency of analysis, around 20 samples per hour |
| Publisher: |
Universidad de Los Andes (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 4 of 10 found articles
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