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Details for article 52 of 143 found articles
| Title: |
ELECTROCHEMICAL STUDY OF THE INTERACTION OF DOXORUBICIN WITH ANIONIC SURFACTANTS (SODIUM LAURYL SULFATE) |
| Author: |
Iuliana Serbanescu Daniela Bulcu Elena Volanschi |
| Appeared in: |
Analele Universitatii Bucuresti. Chimie |
| Paging: | Volume XIV (2005) nr. I-II pages 369-376 |
| Year: |
2005 |
| Contents: |
The interaction between an antitumoral drug, doxorubicin, and an anionic surfactant,sodium lauryl sulfate (SDS), is investigated by cyclic voltammetry. The cyclic voltammogramsrecorded in phosphate buffer (pH=7.09) in the presence of SDS indicate a shift of the peakpotentials of the first monoelectronic reversible couple towards negative values and a decrease ofthe cathodic peak current. Using non-linear fitting of the experimental data, values of the bindingconstant, K and 1:1 stoechiometry of the interaction were determined. The results outline a weakpredominantly electrostatic drug – surfactant interaction in the range of pre-micellar and micellarconcentrations of surfactant (SDS). |
| Publisher: |
Ars Docendi Publishing House (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 52 of 143 found articles
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