Digitale Bibliotheek
Sluiten Bladeren door artikelen uit een tijdschrift
 
   volgende >>
     Tijdschrift beschrijving
       Alle jaargangen van het bijbehorende tijdschrift
         Alle afleveringen van het bijbehorende jaargang
           Alle artikelen van de bijbehorende aflevering
                                       Details van artikel 1 van 4 gevonden artikelen
 
 
  Antimicrobial Susceptibility of Bloodstream Isolates of Staphylococcus aureus: Global Results from the Tigecycline Evaluation and Surveillance Trial, 2004-2008
 
 
Titel: Antimicrobial Susceptibility of Bloodstream Isolates of Staphylococcus aureus: Global Results from the Tigecycline Evaluation and Surveillance Trial, 2004-2008
Auteur: Daniel Amsterdam
Geoffrey Coombs
Michael Dowzicky
Verschenen in: American journal of infectious diseases
Paginering: Jaargang 6 (2010) nr. 1 pagina's 1-7
Jaar: 2010
Inhoud: Problem statement: The Tigecycline Evaluation and Surveillance Trial (TEST) commenced in 2004 to monitor the activity of tigecycline, a new glycylcycline and numerous comparators against major hospital-and community-associated pathogens. In this report we examine the efficacy of tigecycline and comparators against isolates of Staphylococcus aureus collected from blood. Approach: Almost 4000 blood-derived isolates of Staphylococcus aureus were collected from participating centers globally between 2004-2008. Results: All isolates were susceptible to tigecycline (MIC90 0.25 mg L-1) and linezolid (MIC90 4 mg L-1); 99.9% of isolates were susceptible to vancomycin (MIC90 1 mg L-1). Tigecycline and linezolid activity were unaffected by resistance to methicillin, ICU vs non-ICU isolate collection or the age of patients from which the isolates were collected. Although 95.3% of MSSA were levofloxacin susceptible, only 14.4% of MRSA isolates were susceptible to levofloxacin in this study. Conclusion: Tigecycline is shown here to be active against S. aureus isolates collected from blood and is unaffected by methicillin resistance. However, tigecycline is not as yet approved for the treatment of bacteremic infections.
Uitgever: Science Publications (provided by DOAJ)
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details van artikel 1 van 4 gevonden artikelen
 
   volgende >>
 
 Koninklijke Bibliotheek - Nationale Bibliotheek van Nederland