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Details for article 11 of 14 found articles
| Title: |
The Lipid-Lowering Efficacy of Switching Within Non-Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients |
| Author: |
A.M. Bain K.D. Payne A.P. Rahman R. Bedimo D.O. Maclayton M. Rodriguez-Barradas A.J. Busti |
| Appeared in: |
American journal of infectious diseases |
| Paging: | Volume 4 (2008) nr. 2 pages 147-151 |
| Year: |
2008 |
| Contents: |
The objective of present research is to evaluate the lipid lowering efficacy and safety of switching within non-nucleoside reverse transcriptase inhibitors (NNRTI) in HIV-infected patients.This is a multicenter, retrospective study utilizing a comprehensive electronic patient registry to identify all adult HIV-infected patients seen from October 1, 1998 through October 1, 2006, whosubstituted efavirenz for nevirapine (EFV®NVP) or vice-versa (NVP®EFV), without change in other antiretrovirals. Lipid profiles before and after the switch were analyzed. A total of 124 patients were identified with 14 male (EFV®NVP, n = 9; NVP®EFV, n = 5) patients meeting the strict criteria for inclusion. An EFV®NVP switch resulted in significant reductions in TC -16% and non-HDL -25%(p£0.02) and a trend towards a reduction in LDL-C -12%, TG -27%, TC/HDL -23%, TG/HDL -48% and an increase in HDL-C +15% without any changes to BMI, viral or immunological control. However, a NVP®EFV switch appeared to result in a non-significant worsening of LDL-C +29%, HDL-C -8%, TG +36%, non-HDL +28%, TC/HDL +57% and TG/HDL +46%. Lastly, more patients achieved their lipid goals when switched from EFV to NVP. These data suggest that switching from EFV to NVP-based HAART is associated with lipid improvement, however, switching from NVP to EFV-based HAART is associated with worsening of serum lipids. |
| Publisher: |
Science Publications (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 11 of 14 found articles
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