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| Titel: |
Effects of Bacillus subtilis ‘PB6’ (ATCC - PTA 6737) on Clostridium difficile Associated Diarrhea (CDAD) and Inflammatory Bowel Disease (IBD) in Animal Models |
| Auteur: |
Eric Peys Jerry Varghese Ponusami Suresh Jan Vandenkerckhove Johan Van hemel Ramchand Nanappan Chaniyilparampu Benedikt Sas |
| Verschenen in: |
American journal of infectious diseases |
| Paginering: | Jaargang 3 (2007) nr. 4 pagina's 255-266 |
| Jaar: |
2007 |
| Inhoud: |
The administration of probiotic bacteria is emerging as a potential means of preventing the onset or recurrence of Clostridium difficile associated diarrhea (CDAD) and of attenuating inflammatory activity and preventing relapses in inflammatory bowel disease (IBD). We evaluated the efficacy of Bacillus subtilis ‘PB6’ (ATCC – PTA 6737) in a hamster model of antibiotic-induced CDAD and in a rat model of IBD. CDAD was induced in male Golden Syrian hamsters using C.difficile and clindamycin. These hamsters received either nothing or, by gavage, vancomycin (5 days) or PB6 (low, middle and high dose, 6 days). Diarrhea, body weight loss and mortality were observed inall groups in which CDAD was induced. Intensity of diarrhea and body weight loss was least in the groups treated with vancomycin or with the highest dose of PB6. At the end of the treatment period,vancomycin and the highest dose of PB6 were equally efficient in preventing mortality in this hamster model of CDAD. No adverse effects of PB6 treatment were observed in healthy animals. In maleWistar rats, colitis was induced using a single intrarectal administration of 2,4,6- trinitrobenzenesulfonic acid (TNBS). Treatments consisted of PB6 (low, middle and high dose), Saccharomyces boulardii, mesalazine, infliximab, or no treatment. A possible benefit of the prophylactic use of PB6 was also tested. At the end of the treatment period significant differences in body weight gain, in colon inflammatory edema and in gross morphology of the colon intestinal lining were observed between groups. The groups treated with high dose PB6 could not be distincted from the colitis-free negative control group nor from the group treated with mesalazine. The data presented are suggestive of possible therapeutic effectiveness of PB6 in CDAD and IBD in humans. |
| Uitgever: |
Science Publications (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 14 gevonden artikelen
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