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  Induction of a Soluble Anti-HIV-1 factor (s) with IFN-Γ, IL-10, and ß-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture
 
 
Titel: Induction of a Soluble Anti-HIV-1 factor (s) with IFN-Γ, IL-10, and ß-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture
Auteur: José W. Rodríguez
Nat O. Pagan
María C. Ocasio
Zilka Ríos
Luis A. Cubano
Nawal M. Boukli
Miguel Otero
Robert Hunter
Madhavan P. Nair
Eddy Rios-Olivares
Verschenen in: American journal of infectious diseases
Paginering: Jaargang 3 (2007) nr. 4 pagina's 267-275
Jaar: 2007
Inhoud: Partial immune restoration may be obtained with highly active antiretroviral therapy (HAART), but specific anti-HIV-1 immune responses do not appear to improve substantially. We have demonstrated that a soluble factor(s) induced by a mixture of inactivated influenza and bacterial vaccines called polyantigenic immunomodulator (PAI), possesses strong immunoregulatory and anti-HIV-1 activities. In the present study, we show that culture fluids from both PAI-stimulated peripheral blood mononuclear cells (PBMC) and CD8+ T-cells of HIV-1 infected patients were able to suppressHIV-1 replication in an MHC-unrestricted fashion. The PAI-induced antiviral activity was eliminated when culture fluids were pre-heated at 100oC for 10 min. and it is associated with induction of IFN-g,MIP-1a, MIP-1b, and RANTES production, but inhibition of IL-10. Furthermore, this induction is dependent on the immunological status (CD4:CD8 ratio) of the HIV-1 infected patient. Taken together, our results suggest that the MHC-unrestricted HIV-1 suppression that is induced by culture fluids from PAI-stimulated PBMC may result from the stimulation of immune cell subpopulations to produce a heat-labile antiviral soluble factor(s), which in turn modulate cytokine and b-chemokine production. The identification of this PAI-induced soluble factor(s) may have major therapeuticpotential.
Uitgever: Science Publications (provided by DOAJ)
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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