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| Titel: |
Shed Skin of Ophiophagus hannah: Structural Topography and In Vitro Permeation of Nicotine and Phenol |
| Auteur: |
Priprem, A. Pongjanyakul, T. Khamlert, C. Chitropas, P. Kanla, P. Sripanidkulchai, K. |
| Verschenen in: |
American journal of animal and veterinary sciences |
| Paginering: | Jaargang 2 (2007) nr. 4 pagina's 84-88 |
| Jaar: |
2007 |
| Inhoud: |
Scales of the dorsal portions of shed skin of king cobras (Ophiophagus hannah) was usedas the barrier membrane for in vitro permeation of nicotine and phenol at toxic or irritableconcentration levels. The scales were placed between solutions of nicotine or phenol in a donorsolution at pH 5.6 and a receptor solution at pH 7.4. Cumulative amounts of nicotine and phenolpermeated, measured by UV-spectrophotometry which was checked by HPLC, showed a linearrelationship with time (r2 > 0.99), giving permeation rates of 3.76, 8241.98 µg cm–2 h–1 andpermeability coefficients of 0.38×10–3, 90.2×10–3 cm h–1, respectively. Photomicrographs of the scalesby scanning electron microscope (SEM) revealed 3 layers of which the innermost acting as thepermeation barrier. Nicotine and phenol passed the micropits of the outer layer of the scales into themiddle space where the compounds being reserved and then permeated the innermost layer of the skin.It is likely that this might be the pathway that these dose-dependent compounds were absorbed throughsnake skins. |
| Uitgever: |
Science publications (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 10 gevonden artikelen
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