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| Titel: |
Effect of Fig (Ficus carica) Leaf Extract on the Secretion and Content of Cholesterol in Hepg2 Cell |
| Auteur: |
Ahmad Fatemi Ali Rasouli Farzad Asadi |
| Verschenen in: |
American journal of animal and veterinary sciences |
| Paginering: | Jaargang 2 (2007) nr. 4 pagina's 104-107 |
| Jaar: |
2007 |
| Inhoud: |
Traditional medicines remain a source of potential for discovering of new compounds withvaluable pharmacological activities. Leaves of Ficus carica were dried, powdered and extracted usingmethanol (ME).An aliquot of ME was dried and re-extracted by water:chloroform and the otheraliquot by water: peteruleum ether. Effect of aqueous fractions of the former (ACR; 0.08, 0.1 and 0.13mg dL-1), the latter (APR; 0.07, 0.1 and 0.15 mg dL-1) and ME (0.03, 0.05 and 0.08 mg dL-1) of Ficuscarica leaf on the secretion and cell content of cholesterol in HepG2 cells were studied. Extracts wereadded to the media in both basal and glucose stimulated conditions and incubated for 48h.Whileglucose significantly increased cholesterol secretion (17±0.76 mg dL-1) vs basal condition (6.91±0.66mg dL-1), co-incubation with extracts reduced secretion of cholesterol in many concentrations of thestimulated condition. On the other hand, cholesterol content of HepG2 in glucose stimulated condition(2.73±0.39 mg dL-1) showed significant increase compared to the basal status (1.96±0.14 mg dL-1)(p<0.001).Moreover such decrease was shown in response to many concentrations of the extracts.These properties making the hydro-extracts of fig leaf a potentially safe intervention to modulatepostprandial hyperlipidemia. |
| Uitgever: |
Science publications (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 10 gevonden artikelen
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