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Details for article 7 of 17 found articles
| Title: |
Effect of Tumor Necrosis Factor (TNF) On Survivin Expression In NCI-H520 Cell Strain |
| Author: |
Zhao Jian-qing Xing Li-qiang Sun Li |
| Appeared in: |
Al Ameen journal of medical sciences |
| Paging: | Volume 02 (2009) nr. 01 pages 63-66 |
| Year: |
2009 |
| Contents: |
To investigate inhibitory effect of tumor necrosis factor (TNF) on survivin expression in NCI-H520 cell strain. Methods: The NCI-H520 cell strains were treated with TNF at different concentrations. Assayed inhibitory ratio by MTT), mRNA expression by semiquantitative RT-PCR, and expression of survivin by Western-blotting. Results: TNF obviously inhibited the growth of NCI-H520 cell strain, depending on drug concentration. Survivin expression was degraded after treated with TNF for 4 hours, while the expression of survivin mRNA had no obviously changes in NCI-H520 cell strain. Conclusion: TNF can inhibit the growth of NCI-H520 cell strain, which is concentration-dependent and time-dependent. Besides, TNF can decline the expression of Survivin protein, while the expressions of survivin mRNA have no obviously variation. |
| Publisher: |
Dr.B.S.Patil (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 17 found articles
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