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| Titel: |
Sudden Hearing Loss Associated with High Levels of Calcineurin Inhibitors after Liver Transplantation |
| Auteur: |
K. Rifai J. Klempnauer M. P. Manns Ch. P. Strassburg |
| Verschenen in: |
Transplantationsmedizin |
| Paginering: | Jaargang 18 (2006) nr. 1 pagina's 33-35 |
| Jaar: |
2006 |
| Inhoud: |
Hearing impairment in patients after liver transplantation (OLT) has only been reported sporadically. However, potential ototoxic side effects may be related to immunsuppression. We report a series of 5 patients who developed sudden hearing loss after OLT and presented high levels of calcineurin inhibitors at the same time. In 4/5 patients, sudden hearing loss was bilateral. Patients` main characteristic were very heterogenous (e.g. age, time since OLT, underlying liver disease). Sudden hearing loss occured under high levels of tacrolimus (n=3, mean serum levels at the time of hearing loss: 24 ng/ml) and cyclosporine A (n=2, 343 ng/ml), respectively. Further immunosuppression consisted of prednisolone (n=4) and azathioprine (n=1). There were no other risk factors such as administration of ototoxic drugs. Levels of immunsuppressants were rapidly corrected after the event. Nevertheless, in 4/5 patients hearing aids (3/4 bilateral) became necessary during follow-up. Furthermore, two patients suffer from tinnitus since the hearing loss. In conclusion, high levels of calcineurin-inhibitors after OLT seem to be a risk factor for sudden hearing loss. In most cases, hearing loss was irreversible and resulted in need of a hearing aid. Neurotoxicity may be a probable mechanism. Further evaluations are necessary to allow a better understanding of the problem. |
| Uitgever: |
Pabst Science Publishers |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 7 gevonden artikelen
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