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Details for article 7 of 7 found articles
| Title: |
Three Months Lasting Antiviral Prophylaxis Eliminates the Problem of CMV-Infection after Cardiac Transplantation: 6 Years Experience with Ganciclovir |
| Author: |
H. Antretter D. Höfer H. Hangler C. Larcher J. Margreiter Ch. Hörmann G. Pölzl R. Margreiter G. Laufer H. Bonatti |
| Appeared in: |
Transplantationsmedizin |
| Paging: | Volume 15 (2003) nr. 2 pages 97-104 |
| Year: |
2003 |
| Contents: |
Background: Because of intensified immunosuppression patients are at high risk for infection in the early phase after heart transplantation. In this retrospective study the efficacy of a three months lasting antiviral cytomegalovirus (CMV) prophylaxis was evaluated. Patients and methods: Between 1997 and October 2002 123 patients received a three months lasting combined intravenous and oral CMV prophylaxis with Ganciclovir after HTX (group II). They were compared to a historical group consisting of 40 patients, being transplanted during 1995-1996 (group I; CMV-prophylaxis: hyperimmune globuline for the first postoperative month in combination with orally administered aciclovir for 6 months). Demographic data of patients and donors were comparable in both groups except underlying cardiac diseases (p=0.015). All organ recipients had identical immunosuppressive regimes postoperatively. Results: Group II had a significant lower mortality rate (GI: 37.5%, GII 10.6%; p<0.001); one year survival (p=0.0002) and overall survival (p=0.0004) was better than in group I. Patients of group II had less rejection episodes ³ grade II ISHLT requiring treatment (p<0.001). Group II presented significant less positive CMV blood samples (p=0.006), CMV infections (26% versus 47,5% in GI; p=0.008), and a later onset of infection after HTX than group I (group I with a mean of 5.8 weeks after HTX, group II: 24.8 weeks after HTX; p<0.001). Conclusion: Incidence of CMV infections was significantly reduced under ganciclovir prophylaxis, infections were shifted into a later period after HTX in which patients are immunologically more competent. The proportion of higher grade rejection episodes was markedly reduced and patients presented an improved survival. |
| Publisher: |
Pabst Science Publishers |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 7 found articles
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