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| Titel: |
Residues of doxycycline and oxytetracycline in eggs after medication via drinking water to laying hens |
| Auteur: |
Yoshimura, H. Osawa, N. Rasa, F. S. C. Hermawati, D. Werdiningsih, S. Isriyanthi, N. M. R. Sugimori, T. |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 8 (1991) nr. 1 pagina's 65-69 |
| Jaar: |
1991-01 |
| Inhoud: |
Doxycycline (DOTC) and oxytetracycline (OTC) were dissolved in drinking water (0.5 g/l) and supplied to laying hens for 7 consecutive days. Eggs laid were collected daily during and after medication, and the antibiotic concentrations in the yolk and albumin were determined by the cup-plate method with Bacillus cereus var. mycoides ATCC 11778. The concentrations of both antibiotics were increased in yolk day by day with the advance in medication, reached peaks 2 days after withdrawal and then declined gradually. Mean peak concentrations in the yolk were 6.70 μg/g for DOTC and 1.42 μg/g for OTC. Peak concentrations in the albumin occurred in the middle stage of medication, where the mean values were 12.24 μg/g for DOTC and 1.03 μg/g for OTC. DOTC was detected in albumin until 24 days after withdrawal and for 2 days more in yolk than in albumin. OTC was detected in yolk until 9 days after withdrawal. The depletion period of OTC was shorter for the albumin, where the residue disappeared in all eggs 6 days after withdrawal. In spite of similarities between DOTC and OTC in structure, DOTC was deposited in higher concentrations and lasted for a longer period in eggs. This characteristic was considered due to its greater lipophilicity, closely correlated with oral absorption and tissue penetration. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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