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| Titel: |
Residues of Iindane in plasma and fat of sheep after dipping |
| Auteur: |
Dagorn, M. Poul, M. Guillot, P. Sanders, P. |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 5 (1988) nr. 1 pagina's 51-58 |
| Jaar: |
1988-01 |
| Inhoud: |
Ten 5-6 year-old unshorn ewes were dipped in a 0.025% lindane solution. Lindane residues in fat and plasma were analysed by gas liquid chromatography with an electron capture detector. The sensitivity of the method was 0.02 μg/g for fat and 0.005 μg/ml for plasma. Blood samples of 5 sheep were collected up to 84 days. The highest concentration of lindane detected in plasma was 107 ± 37 ng/ml, 48 h after treatment. The disposition of lindane in plasma was studied by linear regression. Omental fat samples were removed by biopsies at 7 or 14 day intervals for 154 days. Fat concentrations of lindane were very high, respectively 30.46 ± 14.6 μg/g, 8.09 ± 4.57 μg/g, and 1.72 ± 0.81 μg/g, 7, 28 and 70 days after dipping. In plasma and fat, the coefficients of elimination calculated by linear regression were similar (0.00190 ± 0.00053 h-1 for plasma, 0.00196 ± 0.00031 h-1 for fat). The tolerance recommended in France (2 μg/g in fat) was obtained 59.7 ± 9.7 days after this treatment. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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