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| Titel: |
A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen |
| Auteur: |
Tansakul, Natthasit Niedorf, Frank Kietzmann, Manfred |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 24 (2007) nr. 6 pagina's 598-604 |
| Jaar: |
2007-06 |
| Inhoud: |
Low level intake of drugs from the ingestion of contaminated feed may lead to residue problems in food animals. Sulfadimidine (SDD) was used as a model to determine the residue risk at various doses in laying hens. The drug was administered as a single intravenous injection (100 mg kg-1 body weight, BW), as a single oral dose (100, 30, 10, 3, 1 mg kg-1 BW) and via medicated feed for 7 consecutive days (30, 10, 3 mg kg-1 BW). Drug levels were determined with HPLC-UV for plasma, yolk and albumen. Pharmacokinetic values, which were calculated using a first-order one-compartment model, residue levels and transfer rates into the eggs were found to be dose-dependent. Even low doses of 3 and 1 mg kg-1 BW resulted in measurable residues in yolk and albumen 1 day after a single oral administration. After ingestion of medicated feed at 3 mg kg-1 BW, mean drug levels at 0.14 ± 0.01 µg g-1 were found in albumen and at 0.09 ± 0.01 µg ml-1 in plasma. Generally, the residue levels in albumen and plasma were higher than in yolk. These findings demonstrate a residue risk for the consumer even after low level intake of drugs. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 11 gevonden artikelen
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