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| Titel: |
Detection of dehydroepiandrosterone and androsterone in a traditional Chinese herbal product |
| Auteur: |
Zou, Peng Chen, Ping Oh, Sharon Sze-Yin Kiang, Kin-Har Low, Min-Yong |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 24 (2007) nr. 12 pagina's 1326-1333 |
| Jaar: |
2007-12 |
| Inhoud: |
Dehydroepiandrosterone (DHEA) and androsterone (ADT) were detected in a traditional Chinese herbal product by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography tandem mass spectrometry (LC-MS/MS). DHEA and ADT were tentatively identified by comparing their electron ionization (EI) mass spectra with those in the GC-MS Wiley database. A multiple reaction monitoring (MRM) scan was performed in LC-MS/MS to confirm the presence of the DHEA and ADT in the herbal product extract. Both the [M + H]+ and the [M + NH4]+ of DHEA and ADT were selected as the precursor ions. DHEA was detected with ion transitions m/z 306.4 → 271.2, 306.4 → 253.3, 289.2 → 270.9, 289.3 → 253.1 while ADT was detected with ion transitions m/z 308.5 → 273.6, 308.5 → 255.3, 291.5 → 273.5, 291.5 → 255.2, which confirmed the presence of the two steroid hormones in the herbal product. Limits of detection (LODs) of 0.2 µg ml-1 for DHEA and 0.3 µg ml-1 for ADT were found in methanolic standard solutions when [M + NH4]+ of DHEA and ADT were selected as the precursor ions, which allowed the detection of DHEA and ADT at trace level without time-consuming derivatization. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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