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| Titel: |
Ergosterol oxidation may be considered a signal for fungal growth and aflatoxin production in Aspergillus parasiticus |
| Auteur: |
De Luca, C. Passi, S. Fabbri, A. A. Fanelli, C. |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 12 (1995) nr. 3 pagina's 445-450 |
| Jaar: |
1995-05 |
| Inhoud: |
The addition of compounds able to peroxidize cell lipids (carbon tetrachloride (CCl4). cumene hydroperoxide (CUH), or linoleic acid hydroperoxide (LAH)) to 5-day-old Czapek-Dox Medium cultures of Aspergillus parasiticus induces a significant reduction of the tri-unsaturated ergosterol (ERG) levels in fungal microsomes and mitochondria, whereas the concentrations of the di-unsaturated linoleic acid (LA; C18:2 n-6) are unaffected. Aflatoxin (AFT) output follows ERG reduction and is associated with both a renewal of fungal growth and a slow increase of ERG concentration in subcellular membranes. We suggest that, by analogy with the regulatory role played on cell proliferation and metabolism by polyunsaturated fatty acid by-products (eicosanoids) in mammalian membranes, by-products of ERG oxidation may be considered triggers sufficient to induce both further fungal growth and AFT biosynthesis. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 35 gevonden artikelen
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