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| Titel: |
Hazard assessment of lead |
| Auteur: |
Carrington, Clark D. Sheehan, Daniel M. Bolger, P. Michael |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 10 (1993) nr. 3 pagina's 325-335 |
| Jaar: |
1993-05 |
| Inhoud: |
Exposure to lead (Pb) continues to be a source of concern for the US Food and Drug Administration and other United States federal regulatory agencies. Blood lead levels as low as 10 μg/dl have been associated with impaired neurobehavioural and cognitive development and electrophysiological deficits in children and reduced gestational age and birth weight in infants. Blood lead levels of 10 μg Pb/dl are also of concern in pregnant women because of exposure to the fetus. Blood lead levels of 30 μg Pb/dl have been associated with elevated blood pressure and other adverse effects in adults. Thus, the values of 10 and 30 μg Pb/dl represent lowest-observed-effects levels for developing and adult populations, respectively. The ingestion levels that result in these blood levels of concern were estimated to be 60 μg Pb/day for children ages 6 years or younger, 150 μg Pb/day for children aged 7 years or older, 250 μg Pb/day for pregnant women and 750 μg Pb/day for adults. Provisional total tolerable intake levels for lead were derived from these blood lead levels for each group by applying the Renwick approach to obtain a tolerable exposure level. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 9 gevonden artikelen
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