A simplified bridge model suitable for use in a parametric study of short-span skew highway bridges and bridges with stiffness eccentricity is presented. The proposed model is simple, yet it captures all essential features that affect the dynamic response of these bridges. Using this simplified model, formulas for computing earthquake response of the bridges are developed and parameters that significantly influence the dynamic response of the bridges are identified. The study indicates that the response of a given skew bridge depends not only on its deck aspect ratio, the stiffness eccentricity ratio, the skew angles, its natural frequencies, but also on the frequency ratio. In particular, the rotational to translational frequency ratio has a pronounced influence on the dynamic response of the bridge. It is found that skew bridges with high rotational to translational frequency ratios often exhibit less dependence on such parameters as deck aspect ratios, stiffness eccentricity ratios and skew angles.