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Details for article 5 of 18 found articles
| Title: |
Conformational changes in the connector protein complex of the bacteriophage φ29 DNA packaging motor |
| Author: |
Tolley, Arron C. Stonehouse, Nicola J. |
| Appeared in: |
Computational & mathematical methods in medicine |
| Paging: | Volume 9 (2008) nr. 3-4 pages 327-337 |
| Year: |
2008-09 |
| Contents: |
DNA packaging in the bacteriophage φ29 involves a molecular motor. It is proposed that dsDNA is packaged through a channel in a connector located at the 5-fold vertex of a preformed prolate icosahedral capsid. The packaging motor also consists of virally-encoded RNA molecules (pRNA) coupled to ATPases. Data obtained from studies using surface plasmon resonance, fluorescence quenching and circular dichroism are presented to demonstrate the importance of the N-termini of the connector protein subunits in pRNA interaction and in conformational change. Based on our findings, we propose a model of DNA packaging based on connector conformational change. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 18 found articles
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