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  Application of a New Processing Method to Post-LDL-apheresis Data
 
 
Title: Application of a New Processing Method to Post-LDL-apheresis Data
Author: Corsini, Franco
Cicero, Arrigo F. G.
Giannuzzi, Antonia
Gaddi, Antonio
Appeared in: Computational & mathematical methods in medicine
Paging: Volume 4 (2002) nr. 3 pages 191-196
Year: 2002
Contents: Our aim was to elaborate a method to optimise treatment intervals for the individual low-density lipoprotein (LDL)-apheresis treated patients. After each treatment, plasma LDL concentrations show a time-related increase with a decreasing speed until a maximum level. We searched to interpret the post-LDL-apheresis experimental data trend as the physical process that produces the observed curve, so that the fitting presupposed theoretical function is a direct consequence of the physic process, because to establish the better time. Applying the proposed fitting method to a succession of 15 samples obtained from the mean of six plasmapheresis executed on five different subjects, small estimate standard error (5 mg/dl) and relative error (1.7%) with a dispersion evidently related to the experimental error were observed. Obviously, applying the same method to a single case, the dispersion is more marked (relative error <5%), with a SE of 10-13 mg/dl, even though the aspect of a casual phenomenon is conserved. Our physical interpretation appears to be a practical model to predict the LDL-rebound kinetic of the single patient.
Publisher: Taylor & Francis
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

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