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Details for article 46 of 88 found articles
| Title: |
1H NMR investigation of the hetero-association of phenanthridine dyes with Daunomycin: effect of substitution of amino with azido groups in the dye chromophore |
| Author: |
Veselkov, Dennis A. Karawajew, Leonid Veselkov, Alexei N. Davies, David B. |
| Appeared in: |
Molecular physics |
| Paging: | Volume 102 (2004) nr. 18 pages 1933-1942 |
| Year: |
2004-09-20 |
| Contents: |
1H NMR spectroscopy at 500 Mhz has been used to determine the structures and thermodynamics in aqueous salt solution of the hetero-association of Daunomycin (DAU) with a series of phenanthridine dyes having different numbers of amino/azido groups in the chromophore, together with the self-association of the phenthridine dyes under the same solution conditions (0.1 M phosphate buffer, pD 7.1, 298 K). The NMR measurements have been analyzed using statistical-thermodynamical models of both self-association and hetero- association in which no limitation is set on the size of molecular stacks. In this work the magnitudes of the self-association parameters of Ethidium Bromide (EB) and its azido-derivatives, 8-azido-Ethidium Bromide (EMB) and 3,8-diazido-Ethidium Chloride (EDC), show a successive decrease with mono- and di-substitition of the 3,8-amino groups of EB. A similar pattern is observed for the equilibrium constants for hetero-association of the phenanthridines with DAU. The thermodynamical and structural parameters of hetero-association of the phenanthridines with DAU are consistent with an intermolecular hydrogen bond between the 3,8 amino-groups of EB and the 9MeCO group of DAU contributing to the stability of the hetero-complex in aqueous solution. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 46 of 88 found articles
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