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Details van artikel 43 van 64 gevonden artikelen
| Titel: |
Seeking for binding determinants of the prion protein to human plasminogen |
| Auteur: |
MENZIANI, M.C. DE BENEDETTI, P.G. LANGELLA, E. BARONE, V. |
| Verschenen in: |
Molecular physics |
| Paginering: | Jaargang 101 (2003) nr. 17 pagina's 2763-2773 |
| Jaar: |
2003-09-10 |
| Inhoud: |
Plasminogen (Pg), a pro-protease implicated in neuronal excitotoxicity, has recently been identified as binding to prion protein (PrP) from several species. Although the precise effect of the binding of PrP to plasminogen in the course of prion-caused diseases has not yet been demonstrated, the implications of this important finding for diagnostic applications are straightforward. In this paper we have investigated the possible modes of interaction of PrP with plasminogen, by means of molecular modelling and computational simulation techniques. To this goal, we first exploited the information available for the mK2Pg/VEK-30 complex in order to identify the PrP residues which satisfy the specific electronic and geometric requirements needed to interact with the kringle lysine binding site, we compared the relevant mK2Pg/VEK-30 and mK2Pg/PrP interactions obtained from the simulated protein—protein complexes and we assessed the docking hypothesis utilized for the mK2Pg/PrP complex by simulating the interaction of PrP with the multi-kringle angiostatin, a more realistic model of the physiological target. The results obtained will be instrumental for planning experiments tailored to clarify the role of the plasminogen activator system in prion-related diseases and, eventually, for mimicking dominant binding determinants through structure-based drug design. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 43 van 64 gevonden artikelen
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