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| Titel: |
Calcitonin Determination by a Fast and Highly Sensitive Enzyme Amplified Immunoassay |
| Auteur: |
Lynch, Catherine Seth, Rashmi Bates, David L. Self, Colin H. |
| Verschenen in: |
Journal of immunoassay and immunochemistry |
| Paginering: | Jaargang 9 (1988) nr. 2 pagina's 179-192 |
| Jaar: |
1988 |
| Inhoud: |
A colorimetric enzyme amplification system was used to develop an immunoassay for human calcitonin (hCT) with a sensitivity of 6 pmol/1, and intra-and inter-assay CVs of 12% and 11.8% respectively for the low pool, and 10% and 11.2% for the high pool. The mean recovery of added synthetic hCT (58.5 pmol) from the plasma of 10 patients was 110% (64.4 pmol). The correlation coefficient between radioimmunoassay (RIA) and amplified enzymoimmunoassay was found to be 0.96 (p 0.001). The assay was successfully applied to the measurement of elevated calcitonin levels in plasma from patients with medullary carcinoma of the thyroid (MCT). MIA offered a reliable and sensitive alternative to RIA for calcitonin determination with the added advantage of convenience as the label employed was much more stable. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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