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| Titel: |
Glutathione S-transferases: Amino acid sequence comparison, classification and phylogenetic relationship |
| Auteur: |
Buetler, Timo M. Eaton, David L. |
| Verschenen in: |
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews |
| Paginering: | Jaargang 10 (1992) nr. 2 pagina's 181-203 |
| Jaar: |
1992 |
| Inhoud: |
We have assembled a data base for 71 full length and near-full length amino acid sequences of glutathione S-transferases from various vertebrate and invertebrate eukaryotic and prokaryotic species. This database was used as input for multiple sequence alignment and a dendrogram was established representing the classification and phylogenetic relationship of the glutathione S-transferase supergene family. The glutathione S-transferase sequences were grouped into six classes; five of them are established classes identified as alpha, mu, pi, theta and microsomal. The lens S-crystallin amino acid sequences from squid and octopus were grouped into a new class termed sigma. A hypothesis of the origin and evolution of glutathione S-transferases is proposed. Glutathione S-transferases are present in primitive prokaryotic organisms and the ancestral gene for glutathione S-transferase probably was a member of the theta class. Gene duplication followed by diversification has led to the multiplicity of glutathione S-transferases known today which comprise almost one hundred individual isozymes. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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