|
| << previous | next >> |
Journal description
All volumes of the corresponding journal
All issues of the corresponding volume
All articles of the corresponding issues
Details for article 4 of 15 found articles
| Title: |
Immunotoxicity in ascidians: Antifouling compounds alternative to organotins - II. The case of Diuron and TCMS pyridine |
| Author: |
Menin, Adams Ballarin, Loriano Bragadin, Marcantonio Cima, Francesca |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 43 (2008) nr. 8 pages 644-654 |
| Year: |
2008-11 |
| Contents: |
Using short-term hemocyte cultures of the colonial ascidian Botryllus schlosseri exposed to various sublethal concentrations of Diuron (3-(3,4-diclorophenyl)-1,1-dimethylurea) and TCMS pyridine (2,3,5,6-tetrachloro-4-(metylsulphonyl)pyridine), we evaluated their immunotoxic effects through a series of cytochemical assays previously used for organotin compounds. At concentrations higher than 250 μ M and 10 μ M for Diuron and TCMS pyridine, respectively, both biocides exerted immunosuppressant effects on Botryllus hemocytes, causing i) deep changes in the cytoskeleton that irreversibly affect cell morphology and phagocytosis, ii) induction of DNA damage, iii) leakage of oxidative and hydrolytic enzymes due to membrane alteration. Unlike organotin compounds, Diuron and TCMS pyridine do not inhibit cytochrome-c-oxidase, and only TCMS pyridine triggers oxidative stress. When co-present, they exert an antagonistic interaction on cytoskeletal components. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 4 of 15 found articles
| << previous | next >> |