|
| << previous | next >> |
Journal description
All volumes of the corresponding journal
All issues of the corresponding volume
All articles of the corresponding issues
Details for article 5 of 9 found articles
| Title: |
Hepatic microsomal enzymes in S. mansoni infected mice: II. effect op duration of infection and lindane administration on aminopyrine demethylase and aniline hydroxylase |
| Author: |
El-Bassiouni, E. A. Mostafa, M. H. El-Sewedy, S. M. El-Meligy, S. Abdel-Aziz, T. Abdel-Rafee, A. |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 19 (1984) nr. 2 pages 193-207 |
| Year: |
1984 |
| Contents: |
The time course of effects of S. mansoni infection on hepatic microsomal drug metabolizing enzymes was studied in swiss albino mice. Aminopyrine demethylase and aniline hydroxylase showed increases in activity, reaching a peak 30 days post infection. Both enzymes demonstrated a steady decline thereafter. On day 60, the level of aminopyrine demethylase was comparable to that of unifected mice. On the other hand, the activity of aniline hydroxylase was lower than the control values. Treatment with lindane (40 mg/Kg/day × 3) increased the activity of both enzymes after different durations of disease induction. Changes in hepatic microsomal enzymes in S. mansoni infection may alter the intensity and duration of pharmacologie or toxic effects of drugs eliminated from the body through metabolic transformation. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 9 found articles
| << previous | next >> |