Effect of quinalphos on blood enzymes and its acute toxicity in bubalus bubalis
Titel:
Effect of quinalphos on blood enzymes and its acute toxicity in bubalus bubalis
Auteur:
Paul, B. S. Singh, S. D. Malik, J. K.
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 19 (1984) nr. 1 pagina's 111-122
Jaar:
1984
Inhoud:
The acute toxic effects of quinalphos (0,0-diethyl 0-2-quinoxalyl phosphorothioata) uere investigated in male buffalo calves. Quinalphos was administered in single oral doses of 5, 7.5, 8.5 and 10 mg/kg body wt. and its effects on erythrocyte and plasma cholinesterases, serum aspartate aminotransferase and blood glucose were studied at various time intervals. The lowest dose (5 mg/kg) produced no apparent toxic symptoms. All the animals given highest dose (10 mg/kg) died within 60-82 hours after dosing. Quinalphos at all the dose levels markedly inhibited the erythrocyte and plasma cholinesterases (68-100%) and significantly elevated the levels of serum aspartate aminotransferase and blood glucose. Seven days after the administration of quinalphos, the blood cholinesterases in survivors remained inhibited to the extent of 41-77% whereas the levels of serum aspartate aminotransferase and blood glucose were comparable to control values.