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Details for article 7 of 13 found articles
| Title: |
In vivo methylation of guanine by the organophosphorus insecticide tetrachlorvinphos |
| Author: |
Zayed, S. M. A. D. Mostafa, I. Y. Adam, Y. Hegazi, B. |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 18 (1983) nr. 6 pages 767-779 |
| Year: |
1983 |
| Contents: |
The in vivo methylating capability of the organophos-phorus insecticide tetrachlorvinphos, assayed by the formation of 7-methyl-guinine in mouse liver, was investigated. Following intraperitoneal injection of male mice with different doses of the 14C-insecticide, labelled at the OCH3 groups, the total and specific radioactivity of nucleic acids and protein were determined. The 14C-labelling in the isolated macromolecules reached its maximum 24 hours following administration of the insecticide. Analysis of the acid hydrolysate of DNA and of RNA on Dowex-50 WX-12 revealed the presence of (7-14C) methylguanine. At maximum 14C-labelling, the amount of radioactive 7-MeGu, calculated as fraction of total dose, was around 9 x 10-5 and 39 x 10-5 for DNA and RNA, respectively. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 13 found articles
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