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Details van artikel 2 van 8 gevonden artikelen
| Titel: |
Development of insecticidal cyclic phosphoryl compounds through chemical and biochemical approaches |
| Auteur: |
Eto, Morifusa |
| Verschenen in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paginering: | Jaargang 18 (1983) nr. 1 pagina's 119-145 |
| Jaar: |
1983 |
| Inhoud: |
Chemical and biochemical studies on three types of cyclic phosphoryl compounds are discussed in connection with the development of insecticides. They are five-membered cyclic phosphoramidates (I), six-membered cyclic phosphates (II) and bridged bicyclic phosphates (III). Development of I has started from the finding of L-leucine as a neuroactive substance in silkworm blood, followed by its combination with chemically active five-membered cyclic phosphates. Studies on the metabolism of neurotoxic tri-o-tolyl phosphate caused the invention of the insecticide salithion in the series of II. Salithion was chemically converted into its thiolo isomers, which is a convenient phosphorylating agent useful to synthesize biologically interesting phosphate esters. III does not inhibit acetylcholin-esterase but acts as an anti-GABA agent. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 8 gevonden artikelen
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